The technology of dry granulator by roller press granulating machine. Chinese herbs with a relative density of extract, the spray drying to obtain dry extract powder, add some accessories, to dry granulating machine pressed into thin slices, and then crushed into particles. The method needs less materials, is helpful to improve the particle stability, disintegration and soluble powder. General dry extract powder and supplementary material 0.5-1 times. However, should also pay attention to, by spray drying of the dry extract hygroscopicity strong. Therefore, application of the key application of this method is to find suitable accessories, accessories should be adhered to some extent, and it is not easy to absorb moisture, such as lactose, mannitol, pregelatinized starch, water-soluble acrylic resin and cellulose derivatives.
Dry compression including dry granulation and direct compression. Dry granulation tabletting method is to put the drugs and dressing after mixing with suitable equipment is pressed into a large (can use the machine or dry granulating machine), and then broken into appropriate size particles, adding lubricant mixing and tabletting. The direct compression method, is as the name suggests a mixture of various materials evenly direct compression.
Dry granulating machine production process:
The formulation design, materials and sieving, mixing, tabletting or determination.
The formulation design, materials and sieving, mixing, crushing, mixing, preparing large -- Determination of content - tablet.
The attention of dry granulator granulation process problem:
Nature 1, drugs and dressings to close, this can avoid uneven mixing. Because the uniformity of mixing similar material bulk density, particle size distribution and other physical properties is good, especially when the concentration of the product needs to do less, content uniformity, if not mixing well big problem.
2, can not be added at the end of lubricant. Pay attention to, must wait for other dressing after mixing evenly, then add not lubricant, and to control the mixing time, otherwise it will affect the disintegration and dissolution.
3, mixing must be done after the content determination.
4, do the prescription design must follow the first pilot to test, finally production principle.
5, tabletting should pay special attention to all kinds of exceptions. May the tabletting process because of equipment vibration caused by film segments, poor uniformity, hardness of tablet weight is not good phenomenon, track record, solve in time, guarantee the quality of the products.
13 to adapt to different biological processes. |
