Dry granulation is one of the most new granulation method developed following the second generation of granulation method "one-step granulation" after. It is an environmental protection type granulating process, energy saving and no pollution, no wetting agent, environmental problems without solvent granulation explosion-proof and exhaust emission pollution; it obviates the drying process, saving a lot of energy; with the new adhesive dry granulation required continuously developed, the cost of a substantial decline in dry granulation.
Dry granulator granulation is the powder, melt, water solution state of the material is processed into certain shape and size of granular operation. The solid preparation of almost all of the preparation process cannot do without dry granulator granulation process. The particles may be the final product such as granules, may also be intermediates, such as tablet.
Dry granulator granulation operation causes the particles with some corresponding, to ensure product quality and the production run smoothly. Such as granules, capsules of particles is the product of dry granulator granulation, the goal is not only to change the flow of materials, like flying, adhesion and is favorable to correct measurement, protect the production environment, and you must ensure that the shape of the particles of uniform size, shape aesthetic. While the particles in tablet production is intermediate, not only to improve liquidity in order to reduce the weight difference of tablets, but also to ensure grain compressibility.
There are many methods of dry granulator granulation, dry granulator granulation method is different, even the same prescription is not only the dry granulating mechanism of particle shape, size, strength not to, and disintegration, dissolution is also different, resulting in different effects. Therefore, should choose the granulator granulation method according to the characteristics required for particle.
The purpose of dry granulator granulation:
Improve liquidity. General granular than powder particle size, around each particle can contact the particle number is less, so the adhesion, aggregation is greatly reduced, thus greatly improving the flow of material, although the material is solid, so that it can be equipped with liquid quantitative treatment may.
�、� to prevent the composition segregation. Prone to segregation phenomenon existed differences in particle size, density of each component of the mixture, mixing dry granulator granulation, or dry granulator granulation mixture can effectively prevent the segregation.
To prevent the adhesion of dust and the wall. Powder dust and adhesion of serious, dry granulator granulation can prevent environmental pollution and the loss of raw materials, is conducive to the management of GMP.
The adjustment of bulk density, solubility.
The improvement of uniform pressure transfer film punishment in production.
The easy to use, easy to carry, improve the value of the goods. |
