With the quality by design idea unceasingly thorough, R & D and production process of drugs and try to more and more by the pharmaceutical industry attention, aiming to solve the production process of drugs in from the experimental zoom to the status of common problems in the process of mass production. Dry granulation technology is a new granulation technology in recent years, which has the advantages of adding materials in traditional Chinese medicine extract powder, can be directly granulation, without wet, mixing, drying and other processes, process is simple, can effectively ensure the quality of traditional Chinese medicine. With the continuous expansion of domestic pharmaceutical industry, especially the traditional Chinese medicine industrialization advancement, dry granulating machine technology and equipment will be further extended. The relevant domestic production enterprises should try to strengthen the technical research and development, improve the domestic equipment problems, to better meet the needs of the market.
Dry granulating method compared with the traditional wet granulation, the powder material is made of granular products directly meet the requirements of the user, without any intermediate and additive, granulating uniform product size, bulk density increased significantly, not only to control pollution, but also reduce the powder material and energy costs, improve the apperance and liquidity, easy storage and transportation, can control the solubility, porosity and specific surface area and so many advantages, especially suitable for wet mixing and granulating, step boiling granulating can not work materials.
Dry granulating machine using the latest rolling control technology, control equipment, the equipment can adjust different materials and the volatility of any physical properties of the same material between different group, the process parameters of dry granulation can be accurate, repeated adjustment, so as to efficiently produce high quality particles. Dry granulation technology by roller press granulating machine. With traditional Chinese medicine the relative density of extract, the spray drying to obtain dry extract powder, add some accessories, to squeeze dry granulating machine pressed into thin slices, and then crushed into particles. The method needs less materials, is helpful to improve the stability of the particles, disintegration and soluble powder.
Future, dry granulating machine will meet the clean and flexible functional requirements. First of all, as the dry granulating system is completely closed, can reduce the dust pollution in the production process, thereby reducing the risk of pollution and pollution; secondly, the equipment adopts a modular design, the granulating device can only use a small amount of tools can be disassembled, convenient for cleaning of all the modules, and can be easily replaced screw and a pressure roller which adapt to different tasks.
Dry granulating machine technology performance without spray drying, spray drying technology is more mature. Dry granulating machine has a very good development prospects, but the technical difficulty is also very big,, have to depend on the government, participate in more industries and scientific research institutions and equipment manufacturers. |
