With the development of science and technology, dry granulating machine widely used in people's daily lives. Dry granulating machine clean, saving drying environment, reduce pollution emissions, is the current widely used is also very promising pharmaceutical equipment. Dry granulating machine is mainly composed of a conveying system, reversing conveying system, extrusion system, crushing system, front cover system, cooling system, whole grain system, hydraulic system, body, cover a few parts plate, rotary screen system, working in the state of complete seal, and all contact with the material component is convenient disassembly and cleaning, effectively prevent dust leakage, reducing the possibility of contamination, reduce the cleaning area, more in line with the requirement of pharmaceutical production GMP.
Dry granulator granulation technology is a new technology in recent years, which has the advantages of adding materials in traditional Chinese medicine extract powder, can be directly granulation, without wet, mixing, drying and other processes, process is simple, can effectively ensure the quality of traditional Chinese medicine. With the continuous expansion of domestic pharmaceutical industry, especially the traditional Chinese medicine industrialization advancement, dry granulating machine technology and equipment will be further extended. The relevant domestic production enterprises should try to strengthen the technical research and development, improve the domestic equipment problems, to better meet the needs of the market.
But a lot of dry granulating machine has some problems, the main problems are: bad, water leakage, roll roll misalignment, producing a large quantity of dust, low yield, difficult to clean, pressure instability.
Dry granulator head easy material, serious when molten material into the labyrinth seals (functions and characteristics of carbonized fiber packing seal packing), production can not be carried out, was forced to stop cleaning, waste time and labor. This problem is of internal revert blanking position unreasonable, easily subject to high temperature, dehydration melting caused by. We according to the characteristics of machine material strong liquidity, in the tail sieve partition design and installation of the material distributor, increase effective screening area more than 90%, thus ensuring the quality of the products (size), will have 1 of 4mm particles can be long-term stability is in 90% above, and smooth, no fine powder.
Dry granulating machine yield is low, can not meet the daily output of more than 110t production load, the reason is that the system size fluctuation, fine powder too much, trunk often blocked, not up to the long period of continuous operation, the device's potential restrictions. Cancel the original machine grading cone, re design and installation of the grading device, completely solve the defects of large particles return head, reduce the crushing load 40% a 50%, yield increased 30%, the slurry index under normal circumstances, the daily amount of 150t, operation and saves, exhaust fan, filter route which can realize continuous operation for more than 60 days without water, realize the long-period continuous operation. Design and transformation of the internal spiral channel in the feed position and movement direction of materials fall head. The eradication of the die material, the device of continuous operation, save the repair expenses.
This is mainly dry granulating machine structure design, many manufacturers will dry granulating machine designed to be simple, without considering the dust problem, it is necessary to update the drugs production norms and ideas. Dry granulator granulation technology is a new, at home and abroad in recent years the pharmaceutical industry and application in the field of development is very rapid. With the further promotion and application of dry granulator industry in the pharmaceutical industry, the related technology and equipment market demand is also showing a trend of expansion.
How to solve the problem of dry granulator production process generated large
Need to adjust the structure, give full consideration to the drug production of dust particles, ensure the production environment. With the GMP requirements increase, introduction of the concept of cGMP, pharmaceutical dry granulating machine must be modified, in order to meet the requirements of. On the dust, there is a need to pay attention to is the dry granulating machine vibration, we know that the vibration will increase the diffusion, particle generation and intensified dust therefore, when manufacturing dry granulator, due account should be taken of the vibration source vibration from the manufacturing accuracy and search the whole structure, reducing vibration, dry granulating machine. |
