Dry granulating machine technology by roller press granulating machine. With traditional Chinese medicine the relative density of extract, the spray drying to obtain dry extract powder, add some accessories, to squeeze dry granulating machine pressed into thin slices, and then crushed into particles. The method needs less materials, is helpful to improve the stability of the particles, disintegration and soluble powder. General dry extract powder and supplementary material 0.5-1 times. Should pay attention to but also, by spray drying of the dry extract hygroscopicity strong. Therefore, application of key application of this method is to find suitable accessories, accessories should be adhered to some extent, also not easy absorption of moisture, such as lactose, mannitol, pregelatinized starch, water-soluble acrylic resin and cellulose derivatives, etc..
Dry granulator is applicable to a variety of materials, so the dry granulating machine pressure, feeding, crushing, pressing, whole grain speed can be adjusted, so that the operation of dry granulator requirements will be higher, general factory manufacturers will provide a relative parameter, but in practice to be reasonable adjustment according to the characteristics of the material and the required particle solid degree, particle size, generally for the material better fluidity, the feeding speed can be slower, easy to form the material pressure may be smaller, the situation for larger particles, grain crushing rate can slow down a bit, as long as not blocking the screen mesh can be, in adjustment, the other parameters unchanged, changing a parameter adjustment.
In adjusting the parameters, as long as the master of the meaning of each parameter can be adjusted in the actual operation, according to the specific circumstances, also depend on trial experience, to achieve the best results.
Dry granulation technology is a new granulation technology in recent years, widely used in rotary dry press roller or flat compression granulation machine. Its advantages are adding accessories in the traditional Chinese medicine extract powder, can be directly granulation, without wet, mixing, drying and other processes, process is simple, can effectively ensure the quality of traditional Chinese medicine.
Double cone rotary vacuum dryer is a set of drying equipment, mixing, vacuum drying in one of its people, as the classical equipment application is simple, convenient and double features, it has a practical and economic, is difficult to substitute other equipment. But in the drying speed of drying under different double cone rotary vacuum dryer and time is also a gap. Double cone rotary vacuum dryer is used more widely raw material medicine production equipment, this is because in the process of vacuum drying, the cylinder pressure is always lower than the atmospheric pressure, less number of gas molecules, low density, low oxygen, so it can dry easily oxidative changes of drug production, can reduce the material contamination opportunity. Because the water in the vaporization process, the temperature and pressure of the steam is directly proportional to the vacuum drying, the moisture in material can at low temperature vaporization, achieve low-temperature drying, especially suitable for heat sensitive materials in pharmaceutical production. |
